Novel role of RNA editing by ADAR2 in core binding factor acute myelogenous leukemia

A team of researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), co-led by Professor Daniel G. Tenen and Associate Professor Polly Chen Leilei, made an unprecedented discovery of a hitherto unappreciated mechanism leading to ADAR2 (adenosine deaminases acting on RNA) dysregulation in core binding factor acute myelogenous leukemias (CBF-AML), and highlighted the functional relevance of the role of ADAR2 role in leukemogenesis. The research was published in the journal Blood on Feb. 16, 2023.