Scientists develop new targeted therapeutic strategies to fight liver metastasis

The research group led by Prof. Zeng Zhutian from the Division of Life Sciences and Medicine of the University of Science and Technology of China (USTC) revealed a new mechanism of immune surveillance by liver-resident macrophages called Kupffer cells (KCs) that prevent liver metastasis from occurring. They also developed a new method for in situ targeted expression and remodeling of KCs’ anti-tumor function, which successfully cleared tumors in various animal models with end-stage liver metastasis, thus providing a new approach to developing clinical immunotherapy for metastatic liver cancers.

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