Study: Mea6 deficiency in oligodendrocytes affects white matter formation in the brain

About half of adult human brain volume is made up of white matter. Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons to form the major components of white matter. Abnormal myelin sheath is associated with many neurological diseases. Mea6/ cTAGE5C is essential for vesicle trafficking from ER to Golgi. However, its biological function in oligodendrocyte and white matter development remains unclear.