NSAIDs vs. acetaminophen: Which over-the-counter medicine should I use?

Pain relievers you buy at the store may be one of the first things you reach for when you hurt yourself, have a headache or backache, or feel discomfort due to some other nagging ailment that doesn’t require a visit to the doctor. Called over-the-counter (or OTC) treatments, you can get these medicines without a prescription, and they will ease pain, bring down a fever, and treat inflammation, depending on which one you take.

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