Wt1 gene found to be a key factor in the endothelial cell during the formation of new coronary vessels

How is the mammals’ heart formed? What role do endothelial cells play? Do the same pathways and genes involved in the formation of the embryonic heart also play a role in repair processes? A new study conducted by a team from the Faculty of Biology and the Institute of Biomedicine of the UB (IBUB) reveals that the deletion of the Wt1 gene in endothelial cells during the early stages of coronary vessel formation affects the correct development of the heart in embryonic stages.