Notable birth cohort effects on the incidence trend of renal replacement therapy in Japan

A Japanese nationwide study revealed the risk of incident end-stage kidney disease (ESKD) requiring renal replacement therapy (RRT) initially rose in the early birth cohorts, peaked, and then declined in more recent birth cohorts in both sexes, but the peaks were different in each sex, showing elevated trends peaking in the 1940–1960s birth cohort for men and for women.