Single-cell study uncovers distinct immunosuppressive tumor microenvironment in brain metastases from kidney cancer

In a new study, researchers from The University of Texas MD Anderson Cancer Center have created the largest single-cell atlas of brain metastases from renal cell carcinoma (RCC) with matched primary and extracranial metastases, enabling the discovery of key biological mechanisms driving an immunosuppressive tumor microenvironment in the brain distinct from that of the kidney or other metastatic sites. Findings were presented today at the American Association for Cancer Research (AACR) Annual Meeting 2023.