Study establishes markers and risk stratification model of intracranial aneurysm instability

Intracranial aneurysm is the leading cause of non-traumatic subarachnoid hemorrhage, with a prevalence of 7% in China. More than 70% of intracranial aneurysms are unruptured intracranial aneurysms (UIAs). Although aneurysm rupture is associated with high morbidity and mortality, previous studies have revealed the rupture rate of UIAs to be as low as 1% per year. Notably, aggressive empirical surgical treatment carries the risk of complications, including ischemic stroke and accidental aneurysm rupture. Evaluating the unstable (rupture and growth) risk of aneurysms is helpful to guide decision making for cases of UIAs.