Investigating acute hepatitis of unknown origin in children

Since Fall 2021, an increasing number of unexplained cases of severe acute hepatitis have been reported in children. Epidemiologic investigation is ongoing, and, to date, a cause of these outbreaks has not been identified. Because adenovirus infection has been detected in some (but not all) cases, it is being investigated as one of many potential causes of the hepatitis. What are the primary known causes of hepatitis?

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