Brain lesions associated with memory loss in multiple sclerosis linked to common brain circuit

Between 30% and 50% of people living with multiple sclerosis (MS) will experience memory problems, but the cause is uncertain. Brain lesions are the hallmark imaging sign used to diagnose MS and are often associated with memory dysfunction. However, increased MS brain lesions are not specific to memory problems, and are also associated with fatigue, walking difficulty and other common MS symptoms. Previous studies that attempted to align the anatomy of lesions associated with memory problems in MS led to conflicting results.