Unraveling the mechanism behind obesity-induced pancreatic β-cell dysfunction

Obesity not only increases the risk of metabolic syndrome-related diseases, such as diabetes, fatty liver, and atherosclerosis, but also remarkably impacts seemingly unrelated conditions, such as cancer, psychiatric disorders, and immune function. To understand this wide range of diseases and develop therapeutic approaches for the same, it is important to elucidate the mechanisms by which various organ and cell functions are impaired in the pathogenesis of obesity.