Cytotoxic CD4+ T-cells correlated to severe and fatal COVID-19 outcomes

Research led by the University of Sydney, Australia, has uncovered an important driver of critical SARS-CoV-2 infections. In their paper, “A unique cytotoxic CD4+ T cell-signature defines critical COVID-19,” published in Clinical & Translational Immunology, the team finds that highly activated and cytotoxic CD4+ T-cell responses may contribute to cell-mediated host tissue damage and the progression of COVID-19.