Study evaluates protein that regulates pigment cell development for role in skin cancer

The microphthalmia-associated transcription factor (MITF) is the master regulator of pigment cell development and, as a lineage survival oncogene, plays a crucial role in the skin cancer melanoma and its resistance to therapy. How MITF distinguishes between its seemingly incompatible differentiation and proliferation-associated targets in the genome has been a bit of a puzzle.