Particular subgroup of antibodies responsible for dengue’s increased deadliness may lead to vaccine

Dengue fever is a viral infection with a devastating twist: those who have caught it once are more likely to develop life-threatening disease the second time around. Why our bodies not only fail to learn from prior infection but also become more vulnerable as a result is a longstanding mystery that has prevented development of a universal dengue vaccine. Rather than protecting against disease, such a vaccine could instead serve as a first exposure to prime the body for it.