Researchers develop preclinical vaccine to regulate immune responses to prevent kidney and heart transplant rejection

A subtype of CD8 T cells, which are classically known to promote immune system responses, may be in fact regulating the immune system by suppressing immune cells causing self-destructive responses leading to autoimmune disorders and organ graft rejection. A team led by researchers from the Department of Medicine and the Transplant Research Center at Brigham and Women’s Hospital, in collaboration with researchers from the Dana-Farber Cancer Institute, has developed a vaccine in preclinical models to promote immune regulation.