DNA sequencing reveals clonal evolution of tumor in childhood leukemia

Researchers at the RUDN Laboratory of Biology of Single Cells have studied the possibilities of DNA sequencing at the level of individual cells in patients with a rare form of childhood leukemia. The study revealed the mechanisms of the clonal evolution of the tumor and its transformation into a more aggressive form of leukemia at the level of individual subclones. It has also been shown that this technology can also be used as a very accurate tool for assessing the response of the disease to the treatment.