YTHDF2’s role in promoting acute myeloid leukemia: The key lies in microRNA processing

In a study published in the journal Genes & Diseases, researchers from Beckman Research Institute of City of Hope, explored the impact of m6A modification on the maturation process of precursor microRNAs (pre-miRNAs) and its potential role in tumorigenesis. They have uncovered a novel mechanism behind the progression of acute myeloid leukemia (AML), a life-threatening blood cancer characterized by rapid expansion of abnormally differentiated hematopoietic cells.