Researchers discover functional compensatory effects in Treg cells

Professor Yi Sun’s team at the Zhejiang University report a functional compensatory effect between the Ube2m-Rbx1 and Ube2f-Sag axes of the neddylation–Cullin-RING ligases (CRLs) system in Treg cells, using conditional KO mouse models. The team also revealed that both Ube2m-Rbx1 and Ube2f-Sag axes are essentially required for the functions of Treg cells, and elucidated mechanistically that the Rbx1/Sag-CRLs function in both neddylation-dependent and -independent manners.