Newly discovered link between FBXW7 mutations and EGFR signaling in colorectal cancer

The Organoid group at the Hubrecht Institute has identified a new link between FBXW7 mutations and epidermal growth factor receptor (EGFR) signaling activity. The FBXW7 gene is commonly mutated in colorectal cancer and such mutations have been associated with worse treatment outcomes. The researchers used colon organoids and the CRISPR/Cas9 gene editing technique to investigate the consequences of multiple common FBXW7 mutations.