Targeting tristetraprolin in basophils: Researchers find promising therapeutic target for allergic inflammation

Inflammation is a crucial part of the body’s defense mechanism, playing a key role in fighting infections and repairing tissue damage. Basophils, a type of immune cell that makes up less than 1% of white blood cells, have recently emerged as critical players in triggering allergic responses by releasing pro-inflammatory cytokines like IL-4. Despite the established role of basophils in inflammation, the molecular mechanisms controlling their cytokine production have remained unclear.