Gene therapy could treat chronic hypereosinophilia

A study published in Human Gene Therapy has involved the generation of a human monoclonal antibody (mAb) directed against human eosinophils. The heavy and light chains of that fully human anti-human eosinophil mAb were delivered via an adeno-associated virus (AAV)-based gene therapy to immunodeficient mice, where they suppressed levels of human eosinophils in vivo.