Unlocking a common cause of ataxia: A step toward effective treatment

Cerebellar rhythm loss due to climbing fiber regression is a shared pathophysiology of motor deficits across cerebellar ataxias. Cerebellar ataxias are a group of genetic and non-genetic disorders that currently have no effective treatment. Despite their different causes, all forms of ataxia share a common set of motor impairments—specifically, a loss of motor rhythm and precision.