Prothrombin concentrate superior to frozen plasma in controlling bleeding during heart surgery

In patients experiencing excessive bleeding during cardiac surgery, a concentrated blood product containing proteins that help the blood clot was significantly more effective and caused fewer adverse effects than frozen plasma, the standard therapy, according to a study presented at the American College of Cardiology’s Annual Scientific Session (ACC.25). The concentrated product, known as four-factor prothrombin complex concentrate (4F-PCC), reduced patients’ risk of experiencing a major bleeding event by close to half compared with standard treatment.