Discovery of α-synuclein’s ‘fuzzy coat’ mechanism offers new insights into Parkinson’s

Parkinson’s disease (PD) and Lewy body dementia (LBD) are incurable and progressive neurodegenerative disorders, with some overlapping symptoms. An estimated 10 million people worldwide live with PD, while the figure for LBD—the second most common form of dementia after Alzheimer’s—is unclear. Both diseases involve Lewy bodies—abnormal clumps of α-synuclein protein in brain cells.