Cell-by-cell roadmap reveals key transcription-factor ‘switches’ in neuroblastoma

High-risk neuroblastoma kills roughly half of affected children because the tumor can switch cell identity and evade therapy. By combining single-cell multi-omics with spatial transcriptomics, researchers at Karolinska Institutet have constructed a cell-by-cell roadmap of these state transitions. The paper is published in the journal Developmental Cell.