Protein complex discovery may unlock DNA repair mechanism in Huntington’s disease

Huntington’s disease is a genetic disorder that kills nerve cells in the brain, causing people to lose their cognitive and motor abilities. New research led by Thomas Jefferson University researcher Anna Pluciennik, Ph.D. is revealing the molecular pathways behind the disease. Along with graduate researcher Fenglin Li, research associate Ashutosh Phadte, and postdoctoral research fellow Mayuri Bhatia, she and the rest of her team found a protein complex that fixes abnormal DNA and could be a potential target for Huntington’s disease.