Researchers at Harvard Medical School have discovered that a molecule made by Streptococcus pyogenes—the bacterium that causes strep throat and other infections—could help explain several long-standing medical mysteries, such as why strep sometimes leads to serious immune complications, including rheumatic fever; how the immune system’s recognition of the molecule may contribute to diseases like lupus; why one of the first cancer immunotherapies showed promise more than 100 years ago; and how current immune therapies for cancer could be more effective.
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