Stretching and stimulating engineered heart tissues to accurately portray hypertrophic cardiomyopathy

A joint effort by a team of academic and industrial researchers led by Associate Professor Yoshinori Yoshida (Department of Cell Growth and Differentiation) created a new modeling system, combining mechanical stretching and chemical stimulation, to generate mature engineered cardiac tissues (ECTs) and employed them to better model hypertrophic cardiomyopathy.