Reprogramming of energy metabolism restores cardiac function after infarction in mice

After birth, the human heart loses its regenerative capacity almost completely. Damage to the heart muscle—for example, due to a heart attack—therefore usually leads to a permanent loss of function in adults. Scientists from the Max Planck Institute for Heart and Lung Research have now shown for the first time in mice that a change in the energy metabolism of heart muscle cells enables heart regeneration.