Hodgkin’s lymphoma: Small changes in cells, big effect

Hodgkin’s lymphoma is one of the most common types of lymphoma in young adults. It is characterized by the presence of enlarged B lymphocytes, which are unusual in that they bear on their surface the identifying markers of many other immune cells—such as those found on phagocytes, dendritic cells, or T cells. Now, a team led by Stephan Mathas from the Experimental and Clinical Research Center (ECRC) has explained how these changes take place in the cells and what impact they have. The ECRC is a joint institution of the Max Delbrück Center and Charité—Universitätsmedizin Berlin.

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