Wnt pathway dysfunction influences colorectal cancer response to immunotherapy, finds study

Colorectal cancer (CRC) presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10–15% of CRC cases, indicates a different clinical trajectory than microsatellite stable (MSS) patients. Notably, MSI patients tend to have better outcomes and respond well to immunotherapy, but not to chemotherapy. The reason behind this disparity and the mechanisms governing MSI remained largely unknown.