Secret vulnerabilities of cancer’s ‘Death Star’ protein revealed

Researchers at the Center for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute near Cambridge, UK, have comprehensively identified the allosteric control sites found in the protein KRAS. These are highly sought after targets for drug development, representing secret vulnerabilities that can be exploited to control the effects of one of the most important causes of cancer. The study presents the first complete control map for any protein and is published in the journal Nature.

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