Advancing the generation of in-vivo chimeric lungs in mice using rat-derived stem cells

Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death worldwide. It is marked by lung damage that is lasting and incurable, leaving lung transplantation as the only viable treatment option. Unfortunately, finding suitable lung donors is difficult. To compensate for this shortage of donors, regenerative medicine is making strides in developing lungs from pluripotent stem cells (PSCs), using interspecies animal models.

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