Researchers find possible neuromarker for ‘juvenile-onset’ Batten disease

Early symptoms can be subtle. A child’s personality and behavior may change, and clumsiness or stumbling develops between the ages of 5 and 10. Over time, cognitive impairment sets in, seizures emerge or worsen, vision loss begins, and motor skills decline. This is the course of Batten disease, a progressive inherited nervous system disorder resulting from mutations to the CLN3 gene.