TLE6 identified as a protein associated with infertility in male mice

Genetic changes are a significant cause of infertility, impacting over 15% of the global population. TLE6, a major protein involved in early embryonic development, is known to affect female fertility. In a recent study, researchers unraveled its role in male fertility using a novel Tle6-deficient mouse model. Abnormal sperm morphology with a marked reduction in sperm count and motility highlighted the role of Tle6 in sperm function and production, and its potential association with male infertility.