‘Hallmarks of cancer’ offer new perspective on malignant transformation and tumor growth

“What is a tumor?” This is the fundamental question to answer if we want to treat cancer effectively. Our vision of cancer and tumors has been evolving with time, from the simplistic bunch of all-similar malignant cells to a more sophisticated, heterogeneous and hierarchical cellular structure, composed of many different cell types. Recently, a new paradigm has emerged: the hallmarks of cancer.

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