MAGE-A4 protein promotes tumor progression by suppressing immune responses, mouse study finds

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body’s immune response critical for their elimination. Researchers at Baylor College of Medicine and collaborating institutions have discovered in a mouse model of non-small cell lung cancer that tumors that express protein MAGE-A4 and have lost the Pten gene, a tumor suppressor, accelerate their development and progression into metastasis.