Genetic study links defects in sugar digestion to irritable bowel syndrome

Sucrase-isomaltase (SI) is an intestinal enzyme critical for the digestion of dietary carbohydrates, particularly sucrose and starch. Previous studies from the Gastrointestinal Genetics team at CIC bioGUNE—BRTA and LUM University suggested a genetic link between SI defects and IBS, whereby certain DNA changes cause reduced enzymatic activity and inefficient digestion of carbohydrates, thus inducing symptoms like bloating, diarrhea, and abdominal pain.