Hormone therapy among older women linked to tau accumulation, a hallmark of Alzheimer’s disease

A new study by Mass General Brigham researchers has found faster accumulation of tau—a key indicator of Alzheimer’s disease—in the brains of women over the age of 70 who took menopausal hormone therapy (HT) more than a decade before. The results, which are published in Science Advances, could help inform discussions between patients and clinicians about Alzheimer’s disease risk and HT treatment.