Integrating genetic and environmental risk assessment to improve stroke prevention

Using a stroke PRS for East Asian populations comprising 534 genetic variants associated with stroke or stroke-related traits identified from large-scale genome-wide association studies (GWASs), Xiangfeng Lu and Dongfeng Gu from Fuwai hospital, Chinese Academy of Medical Sciences & Peking Union Medical College investigated the risk prediction and stratification for the PRS when integrating with a clinical risk score in Chinese large prospective cohorts comprising 41,006 individuals aged 30-75 years with a mean follow-up of 9.0 years.