AmotL2 protein reveals gender differences in abdominal aortic aneurysms

A new study published in Nature Cardiovascular Research uncovers the crucial role of the AmotL2 protein in connecting mechanical forces to endothelial cell integrity and alignment. This discovery sheds light on junctional mechanotransduction and its implications for vascular disease, including abdominal aortic aneurysms (AAA). Importantly, the study reveals gender differences, with males showing a higher incidence of AAA.