Novel senomorphic agent of natural origin found to target aging

Since the discovery of hallmark features of senescence such as cell cycle arrest, apoptosis resistance and development of a senescence-associated secretory phenotype (SASP), efforts in understanding how senescent cells drive physiological and pathological aging have grown exponentially. The accumulation of senescent cells in aging individuals is associated with increased occurrence of age-associated pathologies that contribute to poor health, frailty, and mortality.