A new study reveals the cerebellum as a source of generalized convulsive seizures

Recurrent seizures are debilitating and can sometimes be fatal. The onset and presentation of seizures vary significantly among epilepsy patients. Of more than 25 categories of seizure presentations within epilepsy, those with motor convulsions are perhaps the most disruptive and generally most feared among patients and caregivers. Unfortunately, convulsive seizures are also the most commonly occurring type of generalized seizures. However, little is known about the source or the precise mechanism by which these seizures originate, making it difficult to optimize therapies and develop targeted treatments for these patients.