ChatGPT helps pinpoint precise locations of seizures in the brain, aiding neurosurgeons

Epilepsy, one of the most common neurological disorders characterized by recurrent seizures, affects over 70 million people worldwide. In the United States, about 3.4 million people live with this challenging condition. Around one-third of the epilepsy cases cannot be controlled by medications. For those patients, surgical resection of the epileptogenic zone (EZ), an area whose removal can lead to seizure freedom—a period of time when a person with epilepsy experiences no seizures—can be an effective option to reduce or eliminate seizures.

Molecular approach prolongs ketamine’s antidepressant effects in mice by weeks

Researchers at Vanderbilt University identified a molecular approach to extend the antidepressant effects of ketamine in mice by applying BCI, a compound that inhibits DUSP6 to sustain ERK pathway activation. Findings suggest that BCI modulates the duration of ketamine’s synaptic and behavioral effects, potentially reducing the need for repeated dosing and associated side effects.

Cell-by-cell roadmap reveals key transcription-factor ‘switches’ in neuroblastoma

High-risk neuroblastoma kills roughly half of affected children because the tumor can switch cell identity and evade therapy. By combining single-cell multi-omics with spatial transcriptomics, researchers at Karolinska Institutet have constructed a cell-by-cell roadmap of these state transitions. The paper is published in the journal Developmental Cell.