Gene therapy delivered early can help children with rare neurodegenerative disease retain motor and cognitive functions

If administered early, gene therapy has the potential to change the medical history of children born with metachromatic leukodystrophy (MLD), a rare and lethal neurodegenerative disease of genetic origin which leads to the progressive loss of the ability to walk, talk and interact. This was confirmed by a study published in the New England Journal of Medicine which showed that the therapy, if administered early, is able to preserve motor function and cognitive abilities in most patients.

Brain connectivity study identifies neural mechanisms behind psychosis remission

A study led by Pompeu Fabra University reveals which brain mechanisms allow psychosis to remit. The results of this pioneering research could have important clinical implications for exploring new intervention strategies in patients with psychosis. The study was carried out in collaboration with one of the main psychiatry groups at Lausanne University Hospital (Switzerland).

Simultaneously targeting lysosomal enzyme and KRAS-MAPK pathway eradicates pancreatic tumors in preclinical models

Pancreatic cancer is a leading cause of cancer-related death, with a five-year survival rate of 13%. The high mortality is largely due to a lack of effective therapy options. In a recent paper published in Nature, researchers from the University of Michigan have discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and mouse models.

Regular chicken consumption linked to higher risk of early death from gastrointestinal cancers

A team of health researchers at the National Institute of Gastroenterology, in Italy, has found an association between regularly eating poultry and early death due to digestive system cancers. In their study published in the journal Nutrients, the group analyzed health-related data for 4,869 adults living in Italy over a 20-year period.