AI guidance for clinicians aimed at reducing the spread of Clostridioides difficile—a bacteria that can be deadly for sick patients—was deployed for the first time in a hospital setting, according to a University of Michigan-led study published in JAMA Network Open.
Experimental model for myelodysplastic syndromes uncovers genetic alterations to improve characterization
Myelodysplastic syndromes (MDS) are a group of disorders that typically arise in adulthood, especially after the age of 70, and their five-year survival rate is around 30%. MDS are characterized by defective maturation of blood cells in the bone marrow, leading to a range of health problems such as fatigue and recurrent infections. Without appropriate treatment, they may progress to acute myeloid leukemia, a much more severe disease.
AI tool analyzes blood DNA fragments for faster, affordable cancer monitoring
Scientists from the A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new artificial intelligence (AI)-based method called “Fragle” that makes tracking cancer easier and faster using blood tests.
Excessive use of disinfectants in intensive care patients may raise risk of antibiotic-resistant infections
An international study has, for the first time, revealed a strong and direct link between the rise of antibiotic-resistant bacteria and universal disinfection procedures applied to patients in intensive care units. Published in The Lancet Microbe, the study calls for a reassessment of health care guidelines on the widespread use of disinfectants.
Scientists develop a foundational map of tumor cells for personalized brain cancer treatments
City of Hope researchers have co-led the first study to demonstrate that characterizing genetic material near chromosomes forecasts how mutated, cancer-causing genes reengineer DNA and alter the tumor microenvironment. The brain cancer research provides foundational knowledge that could one day improve the practice of precision medicine and allow oncologists to deliver more personalized therapies to cancer patients.
Aggressiveness responses in mice depend on the instigator, study finds
Displaced aggression, such as lashing out at an unrelated individual after a frustrating experience, is a well-documented phenomenon in both humans and animals.
Potential anti-breast cancer drug identified
A surgeon can excise breast cancer from the body, but even the most skilled scalpel may not be able to remove every cell—especially when the cells have spread from the original disease site elsewhere in the body.
Scientists detect light passing through entire human head, opening new doors for brain imaging
For decades, scientists have used near-infrared light to study the brain in a noninvasive way. This optical technique, known as fNIRS (functional near-infrared spectroscopy), measures how light is absorbed by blood in the brain, to infer activity.
PET-based technique can monitor engineered T cells during immunotherapy
In modern immunotherapy, modified immune cells are introduced into the body to attack tumors and other targets. Researchers at the Technical University of Munich (TUM) have developed a method for tracking these cells in the body. This new approach could deepen our understanding of cellular therapies and help make future treatments safer.
Online education on atrial fibrillation can enhance clinical guideline use by more than 50%
An international study has shown that targeted online education on atrial fibrillation (AF) for health professionals can improve guideline-adherent care. This cluster-randomized controlled trial, published in Nature Medicine this week, was designed to test if structured online AF education for health professionals could improve the care that individual patients receive.