Experimental model for myelodysplastic syndromes uncovers genetic alterations to improve characterization

Myelodysplastic syndromes (MDS) are a group of disorders that typically arise in adulthood, especially after the age of 70, and their five-year survival rate is around 30%. MDS are characterized by defective maturation of blood cells in the bone marrow, leading to a range of health problems such as fatigue and recurrent infections. Without appropriate treatment, they may progress to acute myeloid leukemia, a much more severe disease.

Excessive use of disinfectants in intensive care patients may raise risk of antibiotic-resistant infections

An international study has, for the first time, revealed a strong and direct link between the rise of antibiotic-resistant bacteria and universal disinfection procedures applied to patients in intensive care units. Published in The Lancet Microbe, the study calls for a reassessment of health care guidelines on the widespread use of disinfectants.

Scientists develop a foundational map of tumor cells for personalized brain cancer treatments

City of Hope researchers have co-led the first study to demonstrate that characterizing genetic material near chromosomes forecasts how mutated, cancer-causing genes reengineer DNA and alter the tumor microenvironment. The brain cancer research provides foundational knowledge that could one day improve the practice of precision medicine and allow oncologists to deliver more personalized therapies to cancer patients.

Online education on atrial fibrillation can enhance clinical guideline use by more than 50%

An international study has shown that targeted online education on atrial fibrillation (AF) for health professionals can improve guideline-adherent care. This cluster-randomized controlled trial, published in Nature Medicine this week, was designed to test if structured online AF education for health professionals could improve the care that individual patients receive.