Microbiota poised for diagnostic and therapeutic roles in clinics within 5–10 years, says expert

Both diagnostic and therapeutic use of the microbiota will become reality within the next 5–10 years. It emerges from an “informative” article published in Cell, written by doctors for doctors, to inform clinicians that a series of valuable diagnostic and therapeutic applications based on the microbiome could be just around the corner and bridge the communication gap between basic researchers and clinicians, which is slowing down their implementation.

Patient classification systems can have negative consequences, especially under scarcity

It is well known that both scarcity of resources and expectations of efficacy influence preferences and decisions in health care. But how do these two factors (scarcity and expectations) affect when both are combined? Why, for example, were specific groups of patients (mainly elderly and disabled) so obviously discriminated against during the COVID-19 pandemic, when medical resources were particularly scarce?

Key mechanism that leads to high blood pressure uncovered

When someone has high blood pressure, or hypertension, it results in changes to the walls of their blood vessels. This process is known as arterial or vascular remodeling, which is driven by smooth muscle cells in the blood vessel wall. Researchers at Michigan Medicine have uncovered a key mechanism that regulates blood pressure and vascular remodeling—increasing downstream risk of heart attack and stroke—in people with a genetic variant linked to high blood pressure, a study in both animals and human samples suggests.

Hemophilia B gene therapy demonstrates long-term success

A gene transfer approach to treating the bleeding disorder hemophilia B remains safe and effective long-term, as scientists from St. Jude Children’s Research Hospital and University College London today report thirteen years of follow-up data. Hemophilia B is a rare genetic disorder caused by insufficient levels of a circulating protein called factor IX, which promotes blood clotting.