Inducing prolonged torpor-like state in mice slows epigenetic changes that accompany aging

Surviving extreme conditions in nature is no easy feat. Many species of mammals rely on special adaptations called daily torpor and hibernation to endure periods of scarcity. These states of dormancy are marked by a significant drop in body temperature, low metabolic activity, and reduced food intake—all of which help the animal conserve energy until conditions become favorable again.

Genetic analysis explains rare disease severity, points to possible treatment

Researchers at Washington University School of Medicine in St. Louis have uncovered why some patients with a rare genetic disorder called primary ciliary dyskinesia have worse lung problems than others with the same disorder. The discovery, published in Science Translational Medicine, suggests that gene therapy to restore a missing protein complex could help treat the disease. Patients with the disorder who are treated at WashU Medicine participated in this research.

Hard evidence of soft teeth: The oral symptoms of hypophosphatasia

Hypophosphatasia is a relatively common skeletal disease that primarily affects bone and tooth strength. In the third national dental survey of hypophosphatasia in Japan, recently published in Scientific Reports, researchers analyzed the dental issues faced by Japanese patients in their largest survey to date. Their findings provide valuable information for dentists and medical doctors who treat this often misunderstood disease.

Decoding the neural basis of affective empathy: How the brain feels others’ pain

Empathy—the ability to share and understand the emotions of others—is a cornerstone of human social interactions. When we witness someone in pain, we often experience a mirrored emotional response, a phenomenon known as affect sharing. While this ability is essential for social bonding and survival, the precise neural mechanisms behind empathy remain largely unknown.