A ‘Trojan horse’ approach may enable development of new antimalarial drugs

Antimalarial drug resistance is a pressing issue in combating the spread of malaria worldwide. In a new study, researchers from Children’s Hospital of Philadelphia (CHOP) have discovered a key process where malarial parasites take up a human blood cell enzyme, which could provide a new approach for antimalarial treatment. The findings, published in the journal Proceedings of the National Academy of Sciences, provide new insights into how to design drugs that more effectively treat patients affected by this devastating infectious disease.

Understanding visceral fat: Key to personalized weight-loss strategies

Not all fat is created equal when it comes to weight loss and health. While subcutaneous fat—the fat stored just under the skin—can be neutral or even beneficial, visceral fat is a different story. This deep belly fat, which surrounds vital organs like the liver, pancreas, and intestines, is a major driver of heart disease, diabetes, and chronic inflammation.

Mangoes may help reduce insulin resistance in adults who are overweight or obese

New research has uncovered a potential way to improve cardiometabolic health: fresh mangoes. A study recently published in the journal Nutrients finds that eating two cups of mango, just about 100 calories-worth, daily may help lower insulin concentration levels and improve insulin sensitivity in adults who are overweight or obese with chronic low-grade inflammation. The findings underscore how simple dietary choices could contribute to reducing the risk of chronic conditions like type 2 diabetes, which are closely linked to heart health.

Diagnosing Alzheimer’s disease using blood tests—p-tau biomarkers not as disease-specific as previously thought

Elevated levels of p-tau 181 and 217 in cerebrospinal fluid are considered to reflect early Alzheimer’s disease pathology. However, biomarker detection, which is now part of the diagnostic criteria, requires a lumbar puncture that can be invasive for patients. Recent studies have shown that p-tau proteins can also be detected in the blood of AD patients through highly sensitive assays, which would make diagnosis much easier.

Commentary: Why pediatricians are worried about declining vaccination rates

Early in my career as a pediatrician, it would not be unusual to get a phone call in the middle of the night from the worried parent of a child with a high fever. I got out of bed, met the family in the emergency room and sat with them while their child was evaluated. It could be a terrifying night, with painful tests to rule out serious illnesses like meningitis.