Modifying macrophages in the lung could head off pulmonary hypertension

In the 1980s, when Stella Kourembanas, MD, began her career in neonatology, she cared for newborns with pulmonary hypertension, a disease that results in abnormally high blood pressure in the lung arteries and can lead to heart failure. Since then, treatments like inhaled nitric oxide, new vasodilators, new modalities of mechanical ventilation, and extracorporeal membrane oxygenation (ECMO) have reduced mortality from about 85% to 10%. But pulmonary hypertension still persists.

Diesel exhaust exposure leads to disarray in liver function in mice; could also indicate health issues for humans

UCLA Health researchers have discovered significant changes in liver function following exposure to diesel exhaust (DE) in a controlled study involving mice. The study identified disrupted activity in 658 genes and 118 metabolites. These changes led to a higher production of triglycerides, fatty acids, and sugars, largely due to problems with mitochondria, an organelle in the cell responsible for energy production.

Exploring clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine

Globally, more than 30% of the adult population has metabolic dysfunction-associated steatotic liver disease (MASLD). People with MASLD and more so with metabolic dysfunction-associated steatohepatitis (MASH) and MASLD-associated hepatic fibrosis can progress to cirrhosis and hepatocellular carcinoma and are at increased risk of developing type 2 diabetes, cardiovascular disease, chronic kidney disease, and extrahepatic cancers.

Foundation AI model predicts postoperative risks from clinical notes

Millions of Americans undergo surgery each year. After surgery, preventing complications like pneumonia, blood clots and infections can be the difference between a successful recovery and a prolonged, painful hospital stay—or worse. More than 10% of surgical patients experience such complications, which can lead to longer stays in the intensive care unit (ICU), higher mortality rates and increased health care costs. Early identification of at-risk patients is crucial, but predicting these risks accurately remains a challenge.

Youth with concussion may benefit from monitoring sleep and limiting daytime naps, study finds

Researchers at Nationwide Children’s Hospital have found that when it comes to concussion recovery, sleep matters. In a study published in the British Journal of Sports Medicine, researchers found that limiting daytime sleep and getting approximately seven hours of sleep each night in the first week after a concussion may speed up recovery.